The purpose of present study was to examine pharmacological effect of Artemisia Iwayomogi methanol extract(AIME) on biochemical parameters(activities of AST, A7:.T, LDH, and ALP, contents of total bilirubin, total protein, albumin and A/G ratio in serum and levels of hepatic microsomal lipid peroxide and glucose-6-phosphatase activities) against hepatic injury by carbon tetrachloride(CCl₄) in rats.
Increased AST, ALT and LDH activities by CCl₄ were decreased in AIMS treatment group at 48 or 72 hours. Together, increased ALP activity by CCl₄, almost returned toward normal value in AIME treatment group at 72 hours. Serum total bilirubin contents increased to 87, 79 and 31% compared with normal group by CCl₄, which were decreased to 64, 42 and 26% in AIME treatment group at 24, 48 and 72 hours, respectively. Decreased contents of total protein and albumin, and A/G ratio by CCICCl₄, were recovered in AIME treatment group. Hepatic microsomal lipid peroxide levels(nmol malonic dialdehyde/100㎎ protein) increased to 140, 95 and 78% compared with normal group by CCl₄, which were decreased to 107, 74 and 65% in AIME treatment group at 24, 48 and 72 hours, separately. Hepatic microsomal glucose-6-phosphatase activities decreased to 60, 50 and 53% compared with normal group by CCl₄ at 24, 48 and 72 hours, respectively, which were increased at 72 hours in AIME tre,aunent group.
In conclusion, AIME enhanced the amelioration process from CCl₄-induced lipid peroxidation, degeneration of liver cell, and impairment of protein and bilirubin metabolisms
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